In turn, these principles, detailed below, result in a number of responsibilities when devising a governance system for genome editing:
The following principles should undergird the oversight systems, the research on, and the clinical uses of human genome editing: Along with this promise comes the need for ethically responsible research and clinical use. Genome editing holds great promise for preventing, ameliorating, or eliminating many human diseases and conditions.
OVERARCHING PRINCIPLES FOR GOVERNANCE OF HUMAN GENOME EDITING This chapter summarizes the conclusions of the committee relating the overarching principles and conclusions to recommendations for the conduct and oversight of this burgeoning area of research and application. At the same time, genome-editing technologies challenge regulators and the public to evaluate existing governance systems to determine whether there are some genetic alterations that are insufficiently justified, too risky, or too socially disruptive to be pursued at this time. Furthermore, recently developed methods offer the future possibility of editing germline cells to prevent heritable transmission of genetic disease, within the limits of domestic and transnational law. Genome editing is already entering clinical testing for somatic treatment of certain genetic diseases, subject to regulatory systems designed to oversee human somatic cell gene therapy research. Such research is proceeding rapidly within existing oversight systems. Basic laboratory research applying genome-editing methods to human cells, tissues, germline cells, and embryos holds promise for improving understanding of normal human biology, including furthering knowledge of human fertility, reproduction, and development, as well as providing deeper understanding of disease and establishing new approaches to treatment. Genome editing offers great potential to advance both fundamental science and therapeutic applications. Summary of Principles and Recommendations
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